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KMID : 1035220090010010058
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Korean Journal of Neuromuscular Disorders
2009 Volume.1 No. 1 p.58 ~ p.65
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Electrophysiological Diagnosis of Neuromuscular Junction Disorders
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Kwon O-Hyun
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Abstract
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Neuromuscular junction (NMJ) disorder can be primarily diagnosed by its characteristic clinical features. Electrophysiological study of repetitive nerve stimulation test (RNST) or single fiber electromyography (SFEMG) should be considered to do ancillary diagnostic role next to the clinical findings from each patient’s own clinical history and examination. RNST has been considered as a principal electrodiagnostic tool for NMJ disorder, even helping discriminate its underlying pathophysiology, that is, whether it is presynaptic or postsynaptic disorder. To get its optimal sensitivity and specificity, RNST should be applied under the well-designed protocol and with correct technical skills not to get erroneous results subsequently leading misdiagnosis. This article will focus mainly on the principles and the possible fallacies in performing and interpreting RNST and some comment be added about the role of SFEMG in diagnosing NMJ disorders.
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KEYWORD
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Lambert-Eaton myasthenic syndrome, Myasthenia gravis, Neuromuscular transmission, Repetitive nerve stimulation
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